Endocrine Abstracts

Background: Diabetic ketoacidosis (DKA) remains the leading cause of morbidity and mortality in children with type 1 diabetes. In the past few years, both the International Society for Paediatric and Adolescent Diabetes (ISPAD) and the British Society for Paediatric Endocrinology and Diabetes (BSPED) have recommended key changes in the management of DKA. These changes incorporate new evidence to reduce the incidence of cerebral oedema and the increased use of insulin pumps.</p...

Introduction: Guidance on the management of diabetic ketoacidosis (DKA) has recently been updated in an effort to reduce the risk of complications, in particular, cerebral oedema. However, differences in recommendations for children and adults persist making the care of teenagers with DKA confusing and potentially hazardous.Aims: To compare the management of DKA in teenage patients in paediatric and adult care settings in the context of the latest nation...

The British Thyroid Association recommends that a specialist multidisciplinary team (MDT) is responsible for thyroid cancer management. In accordance with this recommendation, a team was formed to manage thyroid carcinoma in a tertiary referral centre. The team included endocrinology, general surgery, ENT, cytology, radiology and radiation oncology consultants.This audit was performed to assess management of thyroid carcinoma before the establishment of ...

Obesity is associated with metabolic and vascular dysfunction. Many models have shown insulin resistance reduces endothelium-dependent vasodilation but this is also seen in obese subjects with normal glucose tolerance. There is also evidence of increased response to vascular injury in obese animals, although the mechanisms underpinning this are not fully understood. This study used a mouse model of diet-induced obesity (DIO) to address the hypothesis that obesity causes metabo...

Introduction: Successful treatment for childhood-onset Hodgkin lymphoma (HL) has highlighted long-term effects of therapy. We review endocrinopathy in HL survivors attending a hospital follow-up clinic and consider, together with published data, appropriate disease screening and monitoring.Method: Retrospective review of notes and investigations from survivors of childhood HL ≥5 years from diagnosis.Results: Forty-four subjec...

Background: Clinical experience has shown that men over 60 years of age frequently (40%) require extended intervals of greater than 12 weeks between administrations of Nebido. No work has assessed whether this is specific to men over 60 years of age.Methods: We analysed men on Nebido over 60 years (n=12, mean age 66 years) and compared them with a BMI matched group aged 40–60 years. We assessed testosterone levels, injection intervals, PSA an...

Background: Maternal thyrotoxicosis affects 0.2% of pregnancies. Pharmacological treatments include carbimazole, methimazole and propylthiouracil. The Endocrine Society recommends the use of propylthiouracil as first line during pregnancy, because of possible associations between carbimazole and congenital anomalies. However, recent reports link propylthiouracil to liver injury in adults, children, pregnant women and fetuses, raising questions over its safety.<p class="abs...

Hypocalcemia is a classic complication after total thyroidectomy, mostly due to post-operative hypoparathyroidism. However others factors, like vitamin D deficiency, may contribute to this hypocalcemia.Objective: To determine if vitamin D preoperative status influence early postoperative serum calcium levels after total thyroidectomy.Patients and methods: Seventy-nine patients (65 women/14 men), mean age 52.8 (±12.7), were inc...

Although obesity affects men and women, the risks of associated metabolic disturbances (e.g. type 2 diabetes) differ between the sexes. Altered peripheral glucocorticoid metabolism may underpin the metabolic consequences of obesity; however, most research exploring this has focused on male animals. This study used a mouse model to investigate the hypothesis that alterations in glucocorticoid metabolism caused by diet-induced obesity (DIO) will be more profound in males than in...

Multiple endocrine neoplasia type 2a (MEN 2a) is an autosomal dominant disorder with an incidence of ~1 in 30 000 of the population. It is characterized by medullary thyroid cancer (MTC), benign or malignant phaeochromocytomas, and parathyroid hyperplasia or tumours.Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome), is also an autosomal dominant disorder; this condition occurs with an incidence of ~1–2 per 100 000 of the population....